Xenbase Image ID: 149368

Figure 3. Most Proteins Change Little in Level from Egg through Tailbud Stages(A) K-means clustering of relative protein abundance into nine clusters using cosine distance, labeled by the number of proteins that fall into each cluster represented by the median curve. The thickness of the median line reflects the number of proteins in the cluster.(B) Histogram of protein dynamicity shows that most proteins do not change much within the surveyed period. The insert shows representative examples: (gray dashed line) TPI1 (Triosephosphate Isomerase 1) is among the flattest possible with δ = 2.0e-04. RPL11 (black) is at the median of the dynamicity distribution (δ = 0.8e-2). OCM2 (a calmodulin) and one of the isoforms of hemoglobin zeta (HBZ), a form of alpha globin produced in the yolk sack of mammals, are among the most dynamic (δ = 0.571; 35 degrees difference) proteins. Color code: red for dynamic, black for flat.(C) Highly abundant proteins are generally flat, while low abundance proteins are mostly dynamic. The density plot of absolute protein concentration in the egg against dynamicity is shown. Image published in: Peshkin L et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

Return to previous page