XB-IMG-149370
Xenbase Image ID: 149370
Figure 5. Discordance of Temporal Patterns in mRNA and Protein Expression(A) Rank correlation (Spearman) within developmental stage between protein and mRNA temporal patterns for ribo-depleted and poly(A)-enriched methods of mRNA measurement.(B) Histogram of Pearson correlation between protein and mRNA temporal change patterns.(C) Exemplary mRNA-protein time series. The ordinates represent the relative concentration of protein to mRNA. Each plot shows the estimated absolute concentration of mRNA and protein.(D) Mutual information between the temporal pattern of expression for mRNA and protein presented as co-clustering into three key trends. The grayscale background reflects the number of genes in each cluster. The left column illustrates that a flat protein pattern may correspond to any mRNA pattern, but if the protein is dynamic, it usually follows respective change in the mRNA concentration (see top of the right column for induction). Criss-cross patterns of anti-correlation are rarely observed (bottom of the right column). Image published in: Peshkin L et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |