Xenbase Image ID: 149419

Fig. 3. Regulation of Pax3-Zic1 targets expression by NC-inducing signals: (A) in animal caps, induction of snail2 and pax3 by co-expression of Chordin (10 pg) and Fgf8a (5 pg) (C+F) is dramatically reduced in the context of embryos injected with Wnt8MO (W8MO; 50 ng). Interference with Wnt signaling pathway did not affect sox2 expression. (B) A majority of Pax3-Zic1 targets followed a pattern of activation in response to NC-inducing signals similar to that of snail2 and pax3, while a limited number of genes did not (C and D). The data are an average of at least three independent experiments. The values were normalized to odc and presented as mean±s.e.m.; (⁎), p<0.05 versus C+F. Image published in: Bae CJ et al. (2014) Copyright © 2014. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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