Xenbase Image ID: 149501

Fig. 3. Large fraction of myelin at metamorphosis is debris. (A) Debris myelin intermediates in TEM micrographs from stage 66 ON cross-sections include myelin whorls associated with axons (i) and debris myelin enwrapped by phagocyte lamellar processes (ii) or within phagocyte soma (iii). (Scale bar: 1 μm.) (B) SBEM-based reconstruction shows a phagocyte (red) using lamellar processes (dark red) to internalize axonal material containing both myelin (blue) and axoplasm (yellow). (Scale bar: 5 μm.) (Additional axons are illustrated in Fig. S3C). (C) Total area of debris myelin per ON cross-section. (D) Percentage of all myelin in the form of debris, per ON cross-section. (E) Mean area of individual debris myelin fragments, per ON cross-section. In C–E, measurements are from traced TEM micrographs. Mean ± SD is shown (n = 6 ONs). *P < 0.05; **P < 0.01; ***P < 0.001 (by the Games–Howell test). Image published in: Mills EA et al. (2015) Copyright © 2015. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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