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Fig. 3. Removal or mutations of the DAD activates Daam1. Expression of GFP-Daam1 does not induce stress fiber formation in serum-starved NIH 3T3 cells or disrupt stress fibers found in NIH 3T3 cells cultured in the presence of serum. GFP-DaamΔDAD, GFP-Daam A2, and GFP-Daam A12 constructs induce morphological changes characterized by numerous protrusions and collapsed stress fibers in NIH 3T3 cells. GFP-C-Daam induces the formation of stress fibers in NIH 3T3 cells, and a mutation within the FH2 domain of C-Daam abolishes the ability of C-Daam to induce stress fibers. Image published in: Liu W et al. (2008) Copyright © 2008. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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