Xenbase Image ID: 150103

Fig. 6. BMP inhibition prevents the intercalation of MCCs, ionocytes and SSCs in the outer layer of the developing Xenopus epidermis. (A-E′) Sectioning through the epidermis at stage 25 revealed that in the BMP MO-injected embryos the supernumerary α-tubulin-positive MCCs (red in A-C′) and v1a-positive ionocytes (red in D-E′) fail to intercalate into the epidermis outer layer. (I-J′) Likewise, the supernumerary tph1-positive SSCs failed to intercalate in stage 35 BMP morphants (red in I-J′). (F-H′,K-M′) Even at later developmental stages, most of the supernumerary MCCs, which expressed the differentiation marker acetylated tubulin (white), were unable to intercalate properly into the outer layer. Image published in: Cibois M et al. (2015) Copyright © 2015. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue tuba4b.L alpha tubulin, alpha-tubulin, tuba4, tuba4a X. laevis Throughout NF stage 25 multiciliated cell epidermis epidermis outer layer tuba4b.L alpha tubulin, alpha-tubulin, tuba4, tuba4a X. laevis Throughout NF stage 35 and 36 multiciliated cell epidermis epidermis outer layer tuba4b.L alpha tubulin, alpha-tubulin, tuba4, tuba4a X. laevis Throughout NF stage 40 multiciliated cell epidermis epidermis outer layer tph1.L X. laevis Throughout NF stage 35 and 36 epidermis epidermis outer layer secretory epithelial cell atp6v1a.L atp6a1, atp6v1a1, atpv1a, ho68, v1a, va68, vma1, vpp2 X. laevis Throughout NF stage 25 epidermis ionocyte Image source: Published Larger Image Printer Friendly View

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