XB-IMG-150384
Xenbase Image ID: 150384
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Fig 7. Estimated densities and calculated functional stoichiometries of the GIRK channel, Gβγ and Gαi/o in oocytes, HEK293 cells and neurons.Comparison of cultured mouse hippocampal neurons, and in oocytes and HEK293 cells expressing GIRK1/2. (A) Cells were subdivided into four groups according to the indicated Ibasal ranges, and channel densities were estimated assuming Iβγ = 2Itotal and Po,max = 0.105. Densities in Gα expression experiments in oocytes were estimated from Itotal in control groups of oocytes expressing GIRK1/2 and m2R only. (B, C) Estimates of Gβγ and Gα available for GIRK activation in the 4 channel density groups. In oocytes and HEK293 cells Ievoked was elicited by ACh via m2R, in neurons—by baclofen acting on GABAB receptors. Image published in: Yakubovich D et al. (2015) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |