XB-IMG-150428
Xenbase Image ID: 150428
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Fig 6. Novel G-V relations of Kv1.2 FRAKT and Kv1.2 G329T in the absence and presence of sevoflurane.(A) Families of whole-oocyte Kv1.2 FRAKT currents in the absence (left) and presence of 1 mM sevoflurane (right). Currents were evoked by step depolarizations from a holding voltage of -100 mV. The steps were delivered in increments of 10 mV from -90 to 130 mV. The scale bars indicate 100 ms and 2 μA. (B) Families of whole-oocyte Kv1.2 G329T currents in the absence (left) and presence of 1 mM sevoflurane (right). Currents were evoked by step depolarizations from a holding voltage of -100 mV. The steps were delivered in increments of 10 mV from -90 to 70 mV. The scale bars indicate 100 ms and 1 μA. (C) G-V relations of Kv1.2 FRAKT (red) and Kv1.2 G329T (blue) under control (open) or with 1 mM Sevoflurane (filled) (N = 6, 4, respectively). Solid lines are the best fits assuming a double Boltzmann equation (Materials and Methods). The best-fit parameters are summarized in Table A in S1 File. Image published in: Liang Q et al. (2015) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |