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Fig 9. Positive modulation by sevoflurane is T1 domain-independent in Kv1.2 and Kv1.2-FRAKT, and T1 domain-dependent in K-Shaw2.(A) Concentration-response relations of various general anesthetics acting on ΔT1-Kv1.2. Solid line is the best fit to the Hill equation for n-butanol. (B) Concentration-response relations of various general anesthetics acting on ΔT1-Kv1.2 FRAKT. Solid lines are the best fits to the Hill equation (propofol and n-butanol) or double Hill equation (sevoflurane, isoflurane, and halothane). Best-fit parameters for results in panels A and B are summarized in Table 1. (C) Concentration-response relations of sevoflurane acting on K-Shaw2 and ΔT1-K-Shaw2. Solid line is the best-fit double Hill equation to the K-Shaw2 data with the following parameters: K1 = 0.08 mM, A1 = 0.18, nH1 = 1, K2 = 4 mM, A2 = 1.4, nH2 = 1. These parameters are similar to those previously published for wild type K-Shaw2 (Table 1) [7]. K-Shaw2 and ΔT1-K-Shaw2 were tested at +60 mV. N = 2–8 oocytes for each dose. Image published in: Liang Q et al. (2015) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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