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Figure 5. Pan-neuronal Ca-α1T knockdown increases sleep.(a) Sleep profiles of over two days of 12 h:12 h light-dark cycles (LD) and two days of continuous darkness (DD). Pan-neuronal knockdown of Ca-α1T (elav > Ca-α1T-IR, orange, n = 44) increases sleep beyond that of the heterozygous Gal4 control (elav-Gal4/+, black, n = 38) and the heterozygous UAS control (UAS-Ca-α1T-IR/+, grey, n = 42). Sleep is plotted in 30 minute intervals. White, black, and grey bars denote light phase, dark phase, and subjective light phase, respectively. ZT, zeitgeber time. CT, circadian time. (b) Quantification of average total sleep over two days of light-dark cycles (LD) and two days of continuous darkness (DD). Data are presented as means ± s.e.m. and analyzed via one-way ANOVA followed by the Tukey-HSD post hoc test. ***p < 0.001. Image published in: Jeong K et al. (2015) Copyright © 2015, Macmillan Publishers Limited. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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