Xenbase Image ID: 150595

Figure 2. Effects of metabolic disorders on Kir6.x channels and the ΔC mutants expressed in Xenopus oocytes. (A) Representative time courses of currents recorded at −80 mV from Xenopus oocytes injected with cRNAs encoding Kir6.1, Kir6.1ΔC45, Kir6.2, and Kir6.2ΔC36. Whole-cell currents were evoked by a series of 300 ms voltage steps (from −120 to +50 mV with 10 mV increments, holding at −10 mV); the raw current traces at the time points (a–d) are shown on right. a: control; b: Na-Azide; c: PNU-37883A; d: BaCl2. (B) The effects of the drugs on currents mediated by Kir6.x channels and the ΔC mutants. Number of oocytes: Kir6.1, n=8; Kir6.1ΔC45, n=15; Kir6.2, n=7; Kir6.2ΔC36, n=17. cP<0.01 vs control. fP<0.01 vs Na-azide (3 mmol/L). Image published in: Li CG et al. (2016) Image downloaded from an Open Access article in PubMed Central. Copyright © 2016 CPS and SIMM Larger Image Printer Friendly View

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