Xenbase Image ID: 150596

Figure 3. Effects of metabolic disorders on the Kir6.2ΔC36 channel with the mutations R50G, K185E and H175A expressed in Xenopus oocytes. (A) Currents recorded from oocytes expressing Kir6.2ΔC36 and its mutants. Whole-cell currents were evoked by a series of 300 ms voltage steps (from −120 to +50 mV with 10 mV increment, holding at −10 mV). (B) The basal currents of Kir6.2ΔC36 and its mutants recorded at −80 mV. n= 9–14 in each column. cP<0.01 vs Kir6.2ΔC36. fP<0.01 vs H175A. (C) The opening effects of Na-azide on Kir6.2ΔC36 and its mutants, the dashed line indicates the control level, n=9–14 in each column. cP<0.01 vs control. fP<0.01 vs Kir6.2ΔC36. Image published in: Li CG et al. (2016) Image downloaded from an Open Access article in PubMed Central. Copyright © 2016 CPS and SIMM Larger Image Printer Friendly View

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