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Figure 6. FoxA1 drastically enhances AR binding to HRE1/1 + Fox and HRE1/2 + Fox constructs. Groups of oocytes were mRNA injected to express AR or AR together with FoxA1 followed by nuclear injection of HRE1/1 + Fox or HRE1/2 + Fox constructs. (A) AR-HRE binding based on DMS methylation protection plotted as a function of nuclear AR concentration. (B) FoxA1-DNA binding based on DMS methylation protection plotted as a function of nuclear AR concentration. Image published in: Belikov S et al. (2016) © The Author(s) 2015. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license Larger Image Printer Friendly View |