XB-IMG-151670
Xenbase Image ID: 151670
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Fig. 4. The ECM protein EFEMP2 inhibits activin signaling downstream of the activated receptor. A) The ECM protein EFEMP2, but not SPARC, inhibited activin-induced mesodermal formation in animal caps. B) EFEMP2 interfered with mesodermal induction by both activin and the activated type I activin receptor ALK4 (CA-ALK4), but did not inhibit mesodermal induction by Smad2 or Smad2-induced animal cap elongation. The doses of RNA used: activin, 2 pg; CA-ALK4, 1 ng; Smad2, 1 ng; EFEMP2, 1 ng. Image published in: Popov IK et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |