Xenbase Image ID: 151674

Fig. 8. PKDCC1 regulates anterior neural patterning. Knockdown of PKDCC1 did not change the expression of the axial and the paraxial mesodermal markers Chd and MyoD or the neural marker Sox2, but reduced the expression domain of the forebrain marker Otx2 and shifted the midbrain marker engrailed (En) anteriorly, indicating that PKDCC1 modulated anterior-posterior neural patterning. Image published in: Popov IK et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue otx2.S otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 X. laevis Throughout NF stage 20 anterior neural tube en2.L En-2, en2-a, en2-b, eng2, engrailed 2, engrailed homolog 2, engrailed-2, maben, xen2 X. laevis Throughout NF stage 20 presumptive midbrain-hindbrain boundary hoxc9-like.L X. laevis Throughout NF stage 20 posterior neural tube spinal cord sox2.L anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Throughout NF stage 20 neural tube preplacodal ectoderm myod1.S mf25, MyoD, myod1-a, myod1-b, myogenic factor 3, XMyoD, XtmyoD X. laevis Throughout NF stage 20 paraxial mesoderm Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + pkdcc.1 MO + NF17 (in situ hybridization) fig.8 Expression Phenotype decreased amount otx2.S expression in pre-chordal neural plate Xla Wt + pkdcc.1 MO + NF17-20 (in situ hybridization) fig.8 Anatomical Phenotype abnormal development of neural plate Xla Wt + pkdcc.1 MO + NF20 (in situ hybridization) fig.8 Expression Phenotype mislocalised en1.L expression in pre-chordal neural plate Larger Image Printer Friendly View

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