XB-IMG-151765
Xenbase Image ID: 151765
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Fig. 8. A model suggesting how Sdc4 might coordinate Fn1-mediated BMP signaling and Fzd7-mediated Wnt/JNK signaling in the foregut The schematic on top shows a section through a Xenopus embryo with a peri-cellular Fn1 matrix (blue) present through out the foregut (fg) and a prominent Fn1 layer between the endoderm and the BMP-expressing cardiac mesoderm (red). The blowup shows a foregut progenitor cell with integrin (Itg) and Sdc4 complexes promoting Fn1 matrix assembly (blue). We postulate that the Fn1 matrix might enhance BMP-receptor interactions to stimulate Smad1/5/8 phosphorylation (pSmad1), which are required to maintain a positive BMP feedback loop and hhex expression. In this model Sdc4-Fn1 also promotes non-canonical Wnt signaling by forming a co-receptor complex with Fzd7 to recruits Dishevelld (Dvl) and activate JNK. Activation of JNK would then promote hhex expression, stimulate foregut cell proliferation (pH3) and stabilize Cdh on the foregut cell surface. Image published in: Zhang Z et al. (2016) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives license Larger Image Printer Friendly View |