XB-IMG-151883
Xenbase Image ID: 151883
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Fig. 2. Comparison of the deduced amino acid sequences of the Xenopus (xa3, GenBank accession number L43057) and human (ha3, GenBank accession
number M59911; Takada et al., 1991) integrin a3 subunits. Also aligned is the deduced sequence of the PCR fragment amplified from XTC cells (PCR3).
Regions of identity with the complete xa3 sequence are indicated by hyphens. Gaps in the alignments are indicated by dots. Amino acid number 1
corresponds to the first amino acid in the mature a3 protein based on direct sequencing of the human a3 N-terminus (Takada et al., 1991). Position
minus32 of ha3 corresponds to the initiating methionine and the beginning of the signal sequence. The single underline at the N-terminus of ha3 corresponds
to the region of the human cDNA used to prepare the hxa3 construct. Conserved cysteines (C) in the extracellular domain of xa3 are indicated in bold; an
additional cysteine in xa3 is underlined (C). Potential N-linked carbohydrate addition sites in the extracellular domain of xa3 are indicated by bold dots. The
putative metal-binding domains are shaded and the predicted transmembrane domain boxed. The putative dibasic cleavage site in the extracellular domain
(KRRRR) is marked by crosses (†). The C-terminal peptide used for antibody production is indicated by the double underline. Image published in: Meng F et al. (1997) Copyright © 1997. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |