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Fig. 2 Effects of WT- and M4A-Smad1 on dorso-anterior development. Embryos were injected in two dorsal blastomeres at the four-cell stage with either WT- or M4A-Smad1 mRNA. Embryos were scored for dorso-anterior development using the modified dorso-anterior index (DAI) scale, by which 5 represents normal development and 0 represents a completely ventralized embryo. At all concentrations tested, expression of M4A-Smad1 produces more severe axial defects than does overexpression of WT-Smad1 (n53 independent experiments). Image published in: Sater AK et al. (2003) Copyright © 2003. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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