Xenbase Image ID: 152219

Supplemental Fig S6. Sdc4 regulates a positive BMP feedback loop to maintain bmp ligand expression. In situ hybridization (A–E) hhex, (F–J) bmp2, (K–O) bmp4+7 or (P–T) wnt11 on bisected NF19 embryos injected with the indicated morpholinos. The number of embryos that exhibited the illustrated phenotype is indicated. Image published in: Zhang Z et al. (2016) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives license Gene Synonyms Species Stage(s) Tissue hhex.L hex, tHex, XHex X. laevis Throughout NF stage 19 endoderm foregut endoderm bmp2.L BMP-2, bmp2-a, bmp2-b, xBMP-2, xbmp2 X. laevis Throughout NF stage 19 endoderm foregut endoderm axial mesoderm prechordal plate bmp4.L bmp-4, bmp2b, bmp2b1, bmp4-a, bmp4-b, DVR-4, ofc11, XBMP-4, xbmp4, zyme X. laevis Throughout NF stage 19 endoderm foregut endoderm mesoderm wnt11.S Wnt11-R, WNT11-related, wnt11a, Wnt11r X. laevis Throughout NF stage 19 endoderm foregut endoderm endomesoderm axial mesoderm prechordal plate bmp7.1.L bmp-7, bmp7, op-1 X. laevis Throughout NF stage 19 endoderm foregut endoderm mesoderm Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + sdc4 MO + NF19 (in situ hybridization) Fig S6 B Expression Phenotype decreased amount hhex.L expression in foregut endoderm Xla Wt + fzd7 MO + NF19 (in situ hybridization) Fig S6 C Expression Phenotype decreased amount hhex.L expression in foregut endoderm Xla Wt + fn1 MO + sdc4 MO + NF19 (in situ hybridization) Fig S6 D Expression Phenotype decreased amount hhex.L expression in foregut endoderm Xla Wt + sdc4 MO + szl MO + NF19 (in situ hybridization) Fig S6 E Expression Phenotype decreased amount hhex.L expression in foregut endoderm Xla Wt + sdc4 MO + NF19 (in situ hybridization) Fig S6 G Expression Phenotype decreased amount bmp2.L expression in foregut endoderm Xla Wt + fn1 MO + sdc4 MO + NF19 (in situ hybridization) Fig S6 I Expression Phenotype decreased amount bmp2.L expression in foregut endoderm Xla Wt + sdc4 MO + szl MO + NF19 (in situ hybridization) Fig S6 J Expression Phenotype decreased amount bmp2.L expression in foregut endoderm Xla Wt + fn1 MO + sdc4 MO + NF19 (in situ hybridization) Fig S6 K Expression Phenotype decreased amount bmp4.L expression in foregut endoderm decreased amount bmp7.1.L expression in foregut endoderm Xla Wt + sdc4 MO + NF19 (in situ hybridization) Fig S6 L Expression Phenotype decreased amount bmp4.L expression in foregut endoderm decreased amount bmp7.1.L expression in foregut endoderm Xla Wt + sdc4 MO + szl MO + NF19 (in situ hybridization) Fig S6 O Expression Phenotype decreased amount bmp4.L expression in foregut endoderm decreased amount bmp7.1.L expression in foregut endoderm Larger Image Printer Friendly View

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