Xenbase Image ID: 152389

Fig. 4. Activation of canonical Wnt signaling negatively affects the migration of transplanted NC cells. Activation of canonical Wnt signaling in NC cells inhibits migration and affects the patterning of the cranial NC streams. The migration of NC transplants from embryos injected with GFP (A), Lef1-GR and GFP (B,C) or Tcf3∆C-GR and GFP (D) RNA was analyzed at tadpole stages. A Migrating GFP transplant. B Lef1-GR transplant that does not migrate. C Lef1-GR transplant showing a NC patterning defect. D Migrating Tcf3∆C transplant. Dashed white lines indicate the embryo head. E Graph summarizing three independent transplantation experiments showing defects in NC migration (n =60). F Graph summarizing the NC patterning defects of the same experiments presented in E. Note that here the migration defects shown in (E) were also counted as patterning defects. Scale bar =200 µm. Image published in: Maj E et al. (2016) Copyright © 2016. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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