Xenbase Image ID: 152487

Figure 3. Aberrant Expression of Normally Asymmetrically Expressed Genes in Chick Embryos Treated with H+/K+-ATPase Inhibitors Identical results were obtained with SCH28080, lansoprazole, and omeprazole and typical examples are shown here. (A–G) HH stage 5 embryos probed for Shh, Wnt8C, and fgf8 expression by in situ hybridization. Treated embryos show bilateral or absent perinodal expression (B, D, E, and G). (H and I) Nodal expression in HH stage 8 embryos. (J and K) Pitx-2 expression seen at HH stage 11. (L–O) Left flank and head mesenchyme expression of Caronte at HH stage 9 (L, red arrowheads). Examples of aberrant expression of both domains in embryos exposed to H+/K+-ATPase inhibitors include bilateral head and flank (M), head but not flank (N), and absent flank with bilateral head (O) expression. In all images, arrowheads indicate normal (red), absent (white), and ectopic (blue) expression. Image published in: Levin M et al. (2002) Copyright © 2002. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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