Xenbase Image ID: 152511

Figure 6. Muz hearts become dilated and lack valves and trabeculaeCoronal plastic sections of stage 42 wt and muz hearts (top rows) numbered from ventral side of cardiac cavity, and indicated by white lines in 3D models (middle rows). v= ventricle, ot= outflow tract , a= atrium. Wild type hearts show a spiral valve in the outflow tract (sections 14, 23, black arrows), and thickening of endocardium preceding atrioventricular valve formation (section 23, black asterisk). Valve formation is not detected in muz hearts, and endocardial lumen is drastically reduced in outflow tract and AVC regions (white arrowheads sections 54, 58, also compare models B and F). Endocardial cushion formation in AVC can also be seen in transverse sections of stage 42 wild type (I, white arrowhead) hearts but not in muz (J). Trabeculation has initiated in the wild type ventricle (I, black arrowheads) but is absent in muz (J). At this stage the ventricular myocardium has a vacuolated appearance in both wt and mutant embryos (I, J black arrows). Middle two rows: 3D projections of outlines of myocardium (A, C, E, G) and endocardium (B, D, F, H) highlight abnormal muz chamber morphology; red = ventricle, green = atrium, blue = outflow tract, orange = endocardium. Muz ventricles are elongated relative to wild type (E, G white arrows). A narrow tube connects muz ventricle and atrium (section 54 and G, black arrowheads; compare to 23, C). Image published in: Abu-Daya A et al. (2009) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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