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Fig. 1. Sulfonylurea block of wild-type and mutant KATP channels. Percentage inhibition of whole-cell KATP channel currents in wild-type (WT) and mutant (as indicated) channels in response to 0.5 mmol/l tolbutamide. Current in the presence of tolbutamide is expressed as a percentage of that in the absence of drug [2, 9, 11–14]. The numbers in parenthesis indicate the number of patients who responded to sulfonylureas (left) out of the total number (right) with the indicated mutation. White bars, all patients responded; grey bars, some patients responded; black bars, no patients responded. The vertical light grey bar indicates the level of block that separates those patients who responded from those who did not Image published in: Babiker T et al. (2016) © The Author(s) 2016. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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