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Figure 1. Screening of chemicals that perturb gastrulation. (a) X‐Gal staining of a normal embryo after injection of nuclear‐localized β‐galactosidase mRNA into dorsal‐vegetal blastomeres at the eight‐cell stage. Cells stained blue are migrating mesodermal cells.44 (b) Vegetal or posterior‐dorsal views of stage 12–12 1/2 normal embryos (end of gastrulation). Arrows indicate blastopores. (d) Experimental sheme. (c, e, f) stage 12 1/2 embryos treated with 0.05% DMSO (control) or test chemicals (50 μM). (g) Stage 14 normal embryos (neurula stage). (h–k) Embryos at stage 14, treated with 0.05% DMSO (control) or test chemicals (50 μM). Bar = 2 mm. Image published in: Tanaka M et al. (2016) © 2016 The Authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives license Larger Image Printer Friendly View

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