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Figure 6. Effects of C‐157 and D‐572 on tumor growth and invasion. (a) SAS cells were injected subcutaneously in nude mice and each compound (20 μM in 50 μL PBS) was injected three times at the same site as depicted. (b) Tumors were sectioned and subjected to HE staining. (c) Axcel cells were injected into the peritoneal cavity, followed by test chemicals (20 μM, 200 μL) as indicated. Arrow heads indicate disseminated tumors in the mesentery. The number of tumor nodules (>1 mm in diameter) in the mesentery was counted. (d) C6 cells were injected intra‐cranially into nude mice, and test compounds (20 μM, 20 μL) were injected as described in the text. Representative histology of the mouse cerebrum at 9 days post‐injection of tumor cells (H&E stain). T indicates the area occupied by tumor cells. (a–d) Five mice per each group were analyzed. Results are shown as means ± SD. *P < 0.05. Bar = 100 μm. Image published in: Tanaka M et al. (2016) © 2016 The Authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives license Larger Image Printer Friendly View

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