XB-IMG-153179
Xenbase Image ID: 153179
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Fig. 4 – Tissue-specific targeting of APP-GFP fusion proteins
in transgenic Xenopus. Fluorescent images of tadpoles
microinjected in the first cell-stage with the constructs
depicted below the respective images. Fluorescence in the
intermediate pituitary (IP) was observed when the AICD-GFP
construct was targeted with the POMC gene promoter
(pPOMC; upper panel), while fluorescence in neuronal cells
was found when the pPOMC APP-GFP construct was used
(middle panel). For comparison, GFP expression driven by the
neural tubulin gene promoter (pNtub: lower panel) is shown.
The transmembrane domain of APP is indicated by a dashed
box. AICD: APP intracellular domain; SP: signal peptide
sequence; pA: poly-adenylation signal. Image published in: Collin RW and Martens GJ (2006) Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |