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Fig. S6. Analysis of floor plate markers reveals two separate populations of medial floor plate. In situ hybridization for indicated markers was performed at stage 10.5–11 (A, C, E, G, I, K, M) and neurula stages (st.14—B, D, F, J, L, N, O; st.16—H, P). Prime panels (B', etc.) show transverse bisections of matching neurula stages (notochord outlined in red). Markers expressed in the organizer (marked by asterisk) at gastrula stages are expressed throughout the dorsal midline and in a narrow domain in the floor plate (A–N') at neurula stages. Netrin expression begins at early neurula stages (st.14, O) in a wider domain than early markers (O', P' compared to B'–N'). We have designated the narrow, early-forming FP the 1° MFP and the wider, later-forming FP the 2° FP. Image published in: Peyrot SM et al. (2011) Copyright © 2011. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue foxd4l1.1.L foxd4, Foxd4l1, foxd4l1.1-a, foxd4l1.1-b, foxd5, foxD5a, FoxD5b, Xfd-12, XFlip, xlFoxD5a, xlFoxD5b, xtFoxD5 X. laevis Sometime during NF stage 10.5 to NF stage 11 dorsal marginal zone foxd4l1.1.L foxd4, Foxd4l1, foxd4l1.1-a, foxd4l1.1-b, foxd5, foxD5a, FoxD5b, Xfd-12, XFlip, xlFoxD5a, xlFoxD5b, xtFoxD5 X. laevis Throughout NF stage 14 notochord neural plate floor plate neural tube foxa4.L fkh1, foxa4-a, foxa4-b, FoxA4a, pintallavis, XFD-1, xfkh1, XFKHI, xkfh-1 X. laevis Sometime during NF stage 10.5 to NF stage 11 dorsal marginal zone blastopore lip foxa4.L fkh1, foxa4-a, foxa4-b, FoxA4a, pintallavis, XFD-1, xfkh1, XFKHI, xkfh-1 X. laevis Throughout NF stage 14 notochord neural plate floor plate neural tube shh.L hedgehog, vhh-1, X-SHH, Xhh, xshh X. laevis Sometime during NF stage 10.5 to NF stage 11 dorsal marginal zone mesoderm upper blastopore lip shh.L hedgehog, vhh-1, X-SHH, Xhh, xshh X. laevis Throughout NF stage 16 notochord hypochord floor plate neural tube neural groove not.L flh, floating head, not-a, not-b, not1, noto, Xnot, Xnot-2, Xnot1, Xnot2, Znot X. laevis Sometime during NF stage 10.5 to NF stage 11 upper blastopore lip dorsal marginal zone dorso-lateral marginal zone presumptive axial mesoderm not.L flh, floating head, not-a, not-b, not1, noto, Xnot, Xnot-2, Xnot1, Xnot2, Znot X. laevis Throughout NF stage 14 notochord neural plate floor plate neural tube circumblastoporal collar axial mesoderm pre-chordal neural plate enc1.2.L Xencr-1 X. laevis Sometime during NF stage 10.5 to NF stage 11 presumptive axial mesoderm dorsal marginal zone upper blastopore lip enc1.2.L Xencr-1 X. laevis Throughout NF stage 14 notochord floor plate neural tube pre-chordal neural plate axial mesoderm foxa1.S fkh2, foxa1-a, foxa1-b, foxa1b, HNF-3 alpha, HNF3 alpha, HNF3-alpha, hnf3a, HNF3alpha, tcf3a, tFoxA1, xfkh2 X. laevis Sometime during NF stage 10.5 to NF stage 11 dorsal marginal zone presumptive axial mesoderm foxa1.S fkh2, foxa1-a, foxa1-b, foxa1b, HNF-3 alpha, HNF3 alpha, HNF3-alpha, hnf3a, HNF3alpha, tcf3a, tFoxA1, xfkh2 X. laevis Throughout NF stage 14 notochord neural plate floor plate neural tube neural groove axial mesoderm ntn1.L netrin 1, Netrin-1, ntn1l, unc-6 X. laevis Sometime during NF stage 14 to NF stage 16 neural plate floor plate neural fold pre-chordal neural plate Image source: Published Larger Image Printer Friendly View

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