Xenbase Image ID: 153506

Figure S2 A, relevant to Figure 2. Additional analyses of the Hh/Gli pathway function in Xenopus. (A) In situ hybridization of Hh pathway components during different stages of Xenopus development prior to and during lung induction. The foregut / presumptive lung region (boxed) and sections through the lung field (dashed line) are shown at NF 34/35. Robust expression of the HH target genes ptch1 and gli1 in the foregut region is not detectable until NF30-32, coincident with the timing of shh induction in the foregut region. Smo, gli2, and gli3 are expressed in foregut mesoderm but not endoderm. Wnt2b is robustly detected at NF 34/35 but not at earlier stages. Image published in: Rankin SA et al. (2016) Copyright © 2016. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue shh.L hedgehog, vhh-1, X-SHH, Xhh, xshh X. laevis Throughout NF stage 20 notochord shh.L hedgehog, vhh-1, X-SHH, Xhh, xshh X. laevis Sometime during NF stage 23 to NF stage 25 head region notochord foregut shh.L hedgehog, vhh-1, X-SHH, Xhh, xshh X. laevis Sometime during NF stage 29 and 30 to NF stage 32 head region foregut lung primordium neural tube pharyngeal region brain shh.L hedgehog, vhh-1, X-SHH, Xhh, xshh X. laevis Sometime during NF stage 33 and 34 to NF stage 35 and 36 foregut lung primordium neural tube pharyngeal region gall bladder primordium dhh.L cephalic hedgehog, chh, desert hedgehog, dhh-1, dhh-a, dhh-b, x-chh, Xchh X. laevis Throughout NF stage 20 endoderm foregut dhh.L cephalic hedgehog, chh, desert hedgehog, dhh-1, dhh-a, dhh-b, x-chh, Xchh X. laevis Sometime during NF stage 23 to NF stage 25 endoderm hindgut foregut dhh.L cephalic hedgehog, chh, desert hedgehog, dhh-1, dhh-a, dhh-b, x-chh, Xchh X. laevis Sometime during NF stage 29 and 30 to NF stage 32 endoderm hindgut foregut dhh.L cephalic hedgehog, chh, desert hedgehog, dhh-1, dhh-a, dhh-b, x-chh, Xchh X. laevis Sometime during NF stage 33 and 34 to NF stage 35 and 36 head region endoderm hindgut foregut ptch1.S patched, patched1, Ptc-1, Ptc1, X-ptc1, XPtc1 X. laevis Throughout NF stage 20 lateral plate mesoderm paraxial mesoderm ptch1.S patched, patched1, Ptc-1, Ptc1, X-ptc1, XPtc1 X. laevis Sometime during NF stage 23 to NF stage 25 lateral plate mesoderm paraxial mesoderm presomitic mesoderm ptch1.S patched, patched1, Ptc-1, Ptc1, X-ptc1, XPtc1 X. laevis Sometime during NF stage 29 and 30 to NF stage 32 head region pharyngeal region lateral plate mesoderm somite ptch1.S patched, patched1, Ptc-1, Ptc1, X-ptc1, XPtc1 X. laevis Sometime during NF stage 33 and 34 to NF stage 35 and 36 head region lateral plate mesoderm pharyngeal region somite smo.L smoothened, X-smoothened, XSmo X. laevis Throughout NF stage 20 cranial neural crest mandibular crest hyoid crest branchial crest optic vesicle paraxial mesoderm presomitic mesoderm smo.L smoothened, X-smoothened, XSmo X. laevis Sometime during NF stage 23 to NF stage 25 optic vesicle cranial neural crest paraxial mesoderm presomitic mesoderm smo.L smoothened, X-smoothened, XSmo X. laevis Sometime during NF stage 29 and 30 to NF stage 32 head region lateral plate mesoderm pharyngeal region hindbrain pronephric mesenchyme smo.L smoothened, X-smoothened, XSmo X. laevis Sometime during NF stage 33 and 34 to NF stage 35 and 36 head region lateral plate mesoderm pharyngeal region pronephric kidney pronephric duct gli1.L Gli-1, X-gli1 X. laevis Throughout NF stage 20 head region paraxial mesoderm gli1.L Gli-1, X-gli1 X. laevis Sometime during NF stage 23 to NF stage 25 paraxial mesoderm presomitic mesoderm head region gli1.L Gli-1, X-gli1 X. laevis Sometime during NF stage 29 and 30 to NF stage 32 head region pharyngeal region somite gli1.L Gli-1, X-gli1 X. laevis Sometime during NF stage 33 and 34 to NF stage 35 and 36 head region lateral plate mesoderm pharyngeal region gli2.L gli4 X. laevis Throughout NF stage 20 optic vesicle paraxial mesoderm neural tube gli2.L gli4 X. laevis Sometime during NF stage 23 to NF stage 25 paraxial mesoderm presomitic mesoderm head mesoderm optic vesicle neural tube gli2.L gli4 X. laevis Sometime during NF stage 29 and 30 to NF stage 32 mesoderm foregut eye head mesoderm brain spinal cord gli2.L gli4 X. laevis Sometime during NF stage 33 and 34 to NF stage 35 and 36 mesoderm foregut head brain eye pharyngeal arch spinal cord gli3.L XGli-3, Xgli3 X. laevis Throughout NF stage 20 neural tube paraxial mesoderm gli3.L XGli-3, Xgli3 X. laevis Sometime during NF stage 23 to NF stage 25 mesoderm foregut paraxial mesoderm tail bud head brain pharyngeal region somite gli3.L XGli-3, Xgli3 X. laevis Sometime during NF stage 29 and 30 to NF stage 32 mesoderm foregut head region pharyngeal region somite gli3.L XGli-3, Xgli3 X. laevis Sometime during NF stage 33 and 34 to NF stage 35 and 36 mesoderm foregut head region pharyngeal region somite spinal cord wnt2b.L wnt-2b, wnt2b-a, wnt2b-b, Xwnt-2b, xwnt2b X. laevis Throughout NF stage 20 anterior neural tube wnt2b.L wnt-2b, wnt2b-a, wnt2b-b, Xwnt-2b, xwnt2b X. laevis Sometime during NF stage 23 to NF stage 25 anterior neural tube wnt2b.L wnt-2b, wnt2b-a, wnt2b-b, Xwnt-2b, xwnt2b X. laevis Sometime during NF stage 29 and 30 to NF stage 32 midbrain wnt2b.L wnt-2b, wnt2b-a, wnt2b-b, Xwnt-2b, xwnt2b X. laevis Sometime during NF stage 33 and 34 to NF stage 35 and 36 midbrain otic vesicle lens placode foregut mesoderm Image source: Published Larger Image Printer Friendly View

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