Xenbase Image ID: 153652

Fig. 13. Comparison of pharyngeal gene clusters in vertebrate genomes. (A) Comparison of pharyngeal cluster 1, which includes transcription factors, nkx2-1, nkx2-8, pax9, and foxa1. In the X. laevis genome, genes from mbip.S to mipol1.S are deleted, but foxa1.S is retained in XLA8S. In actinopterygian genomes, genes from mbip to slc25A21 are retained as a cluster, but genes from mipol to sstr1 are located in a distant genomic region. Teleost genomes only possess one cluster, possibly due to deletion of the duplicated cluster after whole genome duplication. (B) Comparisons of pharyngeal cluster 2, which consists of transcription factors, nkx2-4, nkx2-2, pax1, and foxa2. In the X. laevis genome, duplicated clusters are completely conserved in both XLA5L and 5S. In the coelacanth genome, nkx2-2, pax1, and foxa2 are separated into scaffolds, JH130518, JH128098, and JH128726, respectively, one gene per scaffold. In teleost genomes, duplicated clusters are partially conserved after the teleost-specific, whole-genome duplication. Syntenic gene homologs with foxa genes are indicated with bold letters. HSA, Homo sapiens; XTR, Xenopus tropicalis; XLA, Xenopus laevis; LCH, Latimeria chalumnae (coelacanth); LOC, Lepisosteus oculatus (spotted gar); DRE, Danio rerio (zebrafish); TRU, Takifugu rubripes (fugu); CMI, Callorhinchus milii (elephant shark). Image published in: Watanabe M et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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