Xenbase Image ID: 154074

Fig. S3. Temporal expression of PSC genes. (A-DD) Shown is the expression of foxi1 (A-E), atp6v0a4 (F-J), pendrin (K-O), pendrin-like (P-T), ae1 (U-Y) and ubp1 (Z-DD) across different stages of embryonic development. Embryonic stage (Nieuwkoop and Faber, 1967) is marked in the lower left corner. Note that expression of foxi1 precedes any other PSC marker (compare A with F,K,P,U,Z), that expression of atp6v0a4, pendrin, pendrin-like and ubp1 are all roughly simultaneous (F,K,P,Z), and that ae1 expression does not initiate until several stages later (U). Number of cells expressing pendrin, pendrin-like or ae1 is a subset of all PSCs (for example, compare I with N,T,X; see also Figs 4 and 5 in the main text). Finally, note the ae1 expression in ventral blood islands (arrowhead in Y); a splice variant of mammalian ae1 is strongly expressed in red blood cells (Kopito and Lodish, 1985). References Kopito, R. R. and Lodish, H. F. (1985). Primary structure and transmembrane orientation of the murine anion exchange protein. Nature 316, 234-238. Nieuwkoop, P. D. and Faber, J. (1967). Normal Table of Xenopus Laevis, Amsterdam: North Holland. Image published in: Quigley IK et al. (2011) Copyright © 2011. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue foxi1.L ectodermally-expressed mesendoderm antagonist, ema, FoxI1e, foxi1e, foxi3, Xema, xfoxi1 X. laevis Throughout NF stage 11 ionocyte epidermis foxi1.L ectodermally-expressed mesendoderm antagonist, ema, FoxI1e, foxi1e, foxi3, Xema, xfoxi1 X. laevis Sometime during NF stage 13 to NF stage 18 ionocyte epidermis foxi1.L ectodermally-expressed mesendoderm antagonist, ema, FoxI1e, foxi1e, foxi3, Xema, xfoxi1 X. laevis Sometime during NF stage 26 to NF stage 29 and 30 epidermis proctodeum ionocyte atp6v0a4.L X. laevis Sometime during NF stage 13 to NF stage 20 ionocyte epidermis non-neural ectoderm atp6v0a4.L X. laevis Sometime during NF stage 26 to NF stage 29 and 30 ionocyte epidermis head spinal cord slc26a4.3.L dfnb4, eva, pendrin, tdh2b X. laevis Sometime during NF stage 13 to NF stage 25 ionocyte epidermis non-neural ectoderm slc26a4.3.L dfnb4, eva, pendrin, tdh2b X. laevis Throughout NF stage 29 and 30 ionocyte epidermis head spinal cord slc4a1.L ae1, anion exchanger 1, band 3, band 3 anion exchanger, bnd3, cd233, empb3, epb3, rta1a, wd1 X. laevis Sometime during NF stage 15 to NF stage 24 ionocyte epidermis non-neural ectoderm slc4a1.L ae1, anion exchanger 1, band 3, band 3 anion exchanger, bnd3, cd233, empb3, epb3, rta1a, wd1 X. laevis Throughout NF stage 31 ionocyte epidermis retinal blood vessel spinal cord anterior ventral blood island ubp1.L cp-2, cp2, lbp-1, lbp1, ubp-1 X. laevis Throughout NF stage 13 ventral non-neural ectoderm ionocyte epidermis ubp1.L cp-2, cp2, lbp-1, lbp1, ubp-1 X. laevis Sometime during NF stage 18 to NF stage 29 and 30 ionocyte epidermis non-neural ectoderm Image source: Published Larger Image Printer Friendly View

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