Xenbase Image ID: 154097

Fig. 8. Cholesterol depletion by MβCD potentiates the dkk1 overexpression phenotype. (A) Uninjected embryo showing otx2 expression anteriorly. (B) otx2 expression is reduced after MβCD injection. (C) dkk1 mRNA and β-gal injection at 4-cell stage causes the enhancement of otx2 expression. (D) dkk1 mRNA and β-gal injection at 4-cell stage and MβCD injection at stage 9 increased the otx2 expression domain. Image published in: Reis AH et al. (2016) Copyright © 2016. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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