Xenbase Image ID: 154098

Fig. 9. Membrane microdomains as an additional mechanism of anterior protection from Wnts. (A) The prechordal plate (PcP) is protected from Wnt signals secreted by the posterolateral cells (PLC) through antagonist secretion and CRMM. (B) After cholesterol depletion by MβCD, PcP cells lose the CRMM. The secreted antagonists together with the decreased dkk1 expression make the PcP cells vulnerable to the Wnt signaling and impair head development. Image published in: Reis AH et al. (2016) Copyright © 2016. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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