Xenbase Image ID: 154162

Fig. 7. Gain of Pa2G4 disrupts gene expression in the otocyst. Otic genes are either reduced in intensity or undetected in the otocyst on the injected side (right image, red arrows, pink lineage tracer). Left image shows gene expression in the otocyst (black arrows) on the control side of the same embryo. Green arrows denote reduction in gene expression in the neural crest-derived branchial arches. Note that the otocysts are present in all cases. For all phenotypes in this figure, please see Table 2 for frequencies and the number of embryos analyzed. Image published in: Neilson KM et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue six1.L XSix1 X. laevis Throughout NF stage 28 cranial placode neurogenic placode otic vesicle neural crest cranial neural crest migratory neural crest cell postmigratory neural crest cell pharyngeal arch mandibular arch hyoid arch branchial arch dlx5.L dll3, X-dll3 X. laevis Throughout NF stage 28 pharyngeal arch mandibular arch hyoid arch branchial arch neural crest cranial neural crest migratory neural crest cell postmigratory neural crest cell forebrain telencephalon olfactory placode pax2.L LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 X. laevis Throughout NF stage 28 otic vesicle tbx1.L cafs, cthm, dgcr, dorv, tbx1-a, tbx1-b, tbx1c, vcfs, xtbx1 X. laevis Throughout NF stage 28 otic vesicle pharyngeal arch mandibular arch hyoid arch branchial arch mandibular crest hyoid crest sox9.L cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 X. laevis Throughout NF stage 28 otic vesicle eye retina midbrain pineal gland pharyngeal arch mandibular arch hyoid arch branchial arch mandibular crest hyoid crest otx2.L otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 X. laevis Throughout NF stage 28 otic vesicle eye retina optic vesicle retinal layer midbrain hindbrain irx1.L iro, irx1-a, irx1-b, Xiro, Xiro1 X. laevis Throughout NF stage 28 otic vesicle pharyngeal arch branchial arch hyoid arch midbrain Image source: Published Larger Image Printer Friendly View

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