Xenbase Image ID: 154244

Supplementary Fig 7. Model for the proposed function of the Nlk1-PAPC interaction. A, When PAPC (transmembrane and extracelluar domains in blue) is expressed without Nlk1 its putative phosphorylation sites (S949/S963, green dashes) at the C-terminus (red) are unprotected and it can be targeted for polyubiquitination (violet hexagons) – probably by GSK3β – and subsequently degraded. PAPC molecules that escape degradation regulate Wnt/PCP signaling, convergent extension (CE) movement and tissue separation (TS). B, When Nlk1 (yellow ellipse) is co-expressed, it binds to the C-terminal domain of PAPC and probably protects the phosphorylation sites. This prevents polyubiquitination and leads to stabilization of PAPC proteins at the membrane, promoting its function during gastrulation. Image published in: Kumar R et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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