Xenbase Image ID: 154400

Figure 5. XTbx1-enR disrupts head, pharyngeal apparatus, and heart development. A–D: Lateral (A,C) and ventral (B,D) views of stage 45 embryos. Embryos were injected in both blastomeres at the two-cell stage and selected for externally normal development at stages 19–20. A,B: Control embryos (A,B) develop normally, whereas XTbx1-enR causes particular reduction in head structures, including the eyes. C: Embryos typically display cardiac edema, with an abnormally small and malformed heart (arrowhead). B,D: Particularly striking is the absence of the filter apparatus (compare arrows in B,D) and malformation of the gut (arrowheads). E,F: Dorsal views of Alcian blue-stained stage 46 embryos. E: Cartilage formation in control embryos is normal, with readily distinguishable ceratohyal (CH), Meckel's (MC), and inferior labial (IL) cartilage. F: In XTbx1-enR–injected embryos the ceratohyal cartilage is severely disorganized, while Meckel's and the infra-rostral cartilages are either disrupted or greatly reduced. Image published in: Ataliotis P et al. (2005) Copyright © 2005. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

Return to previous page