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Suppl. Fig. 6. Lineage-specific knock-down of dnah9. Dorsal–-marginal injections (A) predominantly targeted GRP and floor plate (A’–-A’”’’’) and resulted in > 75% of altered Pitx2c gene expression (D). Dorsoal–-lateral marginal injections (B) targeted lateral tissue (neural plate and somites) in addition to GRP and floor plate, which were hit less frequently (B’–-B’”’’’). Efficiency of laterality defects consequently dropped to about 45% (D). Ventral marginal injections (C) resulted in lateral plate and skin targeting (C’–-C’”’’’) and did not affect Pitx2c gene expression on either side (D). Please note that although identical blastomeres were injected in (A) and (B) effects varied very highly significantly (p < 0.001), suggesting limited diffusion. Image published in: Vick P et al. (2009) Copyright © 2009. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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