Xenbase Image ID: 154582

Figure 2 hairy genes are regulated by Notch and BMP pathways. A–F: One blastomere of a 8- to 16-cell stage embryo was injected with mRNA of CM-bmp4 (250 pg; A, D) or DN-bmpr (500 pg; B, E). Note the expansion of hairy2b or hairy2a markers (respectively, arrowheads). In smad4 (1 ng) a decreased expression of hairy2a (C) or hairy2b (F) can be observed with respect to the control. G–I: Microinjection of Su(H)Ank-MT-GR mRNA (700 ng). Note the expansion of the expression of hairy1 (G), hairy2a (H), and hairy2b (I) on the injected side with respect the control. K–M: Microinjection of delta-Stu mRNA (1 ng). Note the decrease in hairy1 (K), hairy2a (L) and hairy2b (M). J,N: Microinjection of icd22-GR (700 ng). Note the expansion in hairy2a (J) and hairy2b (N) expressions. Image published in: Vega-López GA et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, John Wiley & Sons. Gene Synonyms Species Stage(s) Tissue hes4.L H2, hairy2, hairy2a, hairy2b, hes4-a, hes4-b, hes4a, hes4b, Xhairy2, XHairy2a, Xhairy2b X. laevis Throughout NF stage 16 neural crest anterior neural fold notoplate neural groove neural plate border neuroectoderm hes4.S H2, hairy2, hairy2a, hairy2b, hes4-a, hes4-b, hes4a, hes4b, Xhairy2, XHairy2a, Xhairy2b X. laevis Throughout NF stage 16 neural crest anterior neural fold notoplate neural groove neural plate border hes1.L hairy1, hes-1, hes1-a, hes1-b, Xhairy1 X. laevis Throughout NF stage 16 neural plate border pre-chordal neural plate anterior neural fold neural fold Image source: Published Experiment + Assay Source Phenotypes and Disease Xla Wt + dnbmp4 + NF16 (in situ hybridization) Fig.2.a Expression Phenotype increased amount hes4.L expression in neural plate border Xla Wt + dnbmpr1a + NF16 (in situ hybridization) Fig.2.b Expression Phenotype increased amount hes4.L expression in neural plate border Xla Wt + smad4.2 + NF16 (in situ hybridization) Fig.2.c Expression Phenotype decreased amount hes4.L expression in neural plate border Xla Wt + dnbmp4 + NF16 (in situ hybridization) Fig.2.d Expression Phenotype increased amount hes4.S expression in neural plate border Xla Wt + dnbmpr1a + NF16 (in situ hybridization) Fig.2.e Expression Phenotype increased amount hes4.S expression in neural plate border Xla Wt + smad4.2 + NF16 (in situ hybridization) Fig.2.f Expression Phenotype decreased amount hes4.S expression in neural plate border Xla Wt + carbpj-notch1del-GR + NF16 (in situ hybridization) Fig.2.g Expression Phenotype increased amount hes1.L expression in neural plate border Xla Wt + carbpj-notch1del-GR + NF16 (in situ hybridization) Fig.2.h Expression Phenotype increased amount hes4.S expression in neural plate border Xla Wt + carbpj-notch1del-GR + NF16 (in situ hybridization) Fig.2.i Expression Phenotype increased amount hes4.L expression in neural plate border Xla Wt + canotch1-GR + NF16 (in situ hybridization) Fig.2.j Expression Phenotype increased amount hes4.S expression in neural plate border Xla Wt + dndll1 + NF16 (in situ hybridization) Fig.2.k Expression Phenotype decreased amount hes1.L expression in neural plate border Xla Wt + dndll1 + NF16 (in situ hybridization) Fig.2.l Expression Phenotype decreased amount hes4.S expression in neural plate border Xla Wt + dndll1 + NF16 (in situ hybridization) Fig.2.m Expression Phenotype decreased amount hes4.L expression in neural plate border Xla Wt + canotch1-GR + NF16 (in situ hybridization) Fig.2.n Expression Phenotype increased amount hes4.L expression in neural plate border Larger Image Printer Friendly View

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