XB-IMG-154584
Xenbase Image ID: 154584
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Figure 4
hairy genes work as transcriptional repressor. A–H: One blastomere of a four- to eight-cell stage embryo was injected with 700 pg of mRNA of hairy2a and hairy2b repressor construct (A,B, E,F) or the hairy2a and hairy2b activator construct (C,D, G,H), treated with dexamethasone at stage 12.5 and fixed at stage 16, and the expression of neural crest markers snail2 (A,C,E,G) and foxd3 (B,D,F,H) were analyzed. Arrowhead shows injected side. Note that the snail2 repressor construct (hairy2-GR-EnR) produced an expansion in neural crest markers on the injected side (A,B, E,F) while the hairy2a and hairy2b activator lead to inhibition in the expression of the markers (C,D, G,H). Image published in: Vega-López GA et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, John Wiley & Sons.
Image source: Published
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