Xenbase Image ID: 154597

Figure 14 Diagram representing a unified model of the signals involved in neural crest development. Three ectodermal domains are shown (neural plate, neural crest and nonneural ectoderm) and four underlying mesodermal domains (axial, paraxial, intermediate, and lateral). The blue gradient represents BMP activity in the ectoderm. In the lateral domain to the neural crest Notch/Delta signal activates the hairy1 gene that is also involved in neurogenesis in the neural plate and in the specification of the placodes in the nonneural domain. Some regulatory relationships described in this work involving hairy genes are shown in the neural crest region. References: Arrows indicate activation or positive relationships; truncated arrows indicate inhibitory or negative relationships. M, mesoderm. Modified from Huang and Saint-Jeannet ([1]). Image published in: Vega-López GA et al. (2015) Copyright © 2015. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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