Xenbase Image ID: 154716

Fig. 3. Frequent loss ofwnt11bgenes in vertebrate lineages and variable expression patterns ofwnt11ahomeologs. (A) Synteny around the wnt11b gene in vertebrates. wnt11b.S was deleted from X. laevis chromosome 8S (XLA8S) together with neighboring genes. Orthologs of wnt11b were also deleted in humans (HSAX) and medaka (OLA10). After the divergence of Xenopus and Nanorana, a large inversion seems to have occurred between igbp1 and stard10-like, as indicated by dashed lines. (B) Synteny around the wnt11a gene in vertebrates. Although a genomic rearrangement was found in XLA2L, wnt11a orthologs and synteny are highly conserved among vertebrates. HSA, Homo sapiens; GGA, Gallus gallus (chicken); NPA, Nanorana parkeri (Tibetan frog), XTR, Xenopus tropicalis; XLA, Xenopus laevis; LOC, Lepisosteus oculatus (spotted gar); DRE, Danio rerio (zebrafish); OLA, Oryzias latipes (medaka). (C) Expression profiles of wnt11a.L, wnt11a.S and wnt11b.L. Data are shown in graphs similar to those in Fig. 1. See text for detailed explanations of variable expression profiles. Image published in: Michiue T et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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