Xenbase Image ID: 154780

Fig. 4. Induction of hindbrain by noggin and FGF. Expression of Krox 20 (purple) and Muscle actin (blue) in stage 24 control embryos (A) and in stage 10.25 ectoderm treated with 1 mg/ml noggin (B), 50 ng/ml FGF (C), and the mixture of noggin and FGF (D) after culture to stage 24. Whole embryos express Krox 20 in two stripes in the developing hindbrain, while muscle actin is expressed in the somites. Noggin does not induce either gene. FGF can induce muscle actin (1/13 in this experiment); induction of muscle is highly stage-dependent and thus shows some variability between experiments (compare to Fig. 1). FGF may induce a low level of unlocalized Krox 20. FGF + noggin explants show Krox 20 expression localized to a stripe in the central region of the elongated structure, and no muscle actin expression. Image published in: Lamb TM and Harland RM (1995) Copyright © 1995. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue egr2.L EGR-2, Krox-20, krox20, XKr20, XKrox-20 X. laevis Throughout NF stage 24 rhombomere R3 rhombomere R5 hyoid arch actc1.L actc, actna1, cardiac actin, cardiac alpha actin, muscle actin X. laevis Throughout NF stage 24 somite Image source: Published Larger Image Printer Friendly View

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