Xenbase Image ID: 154783

Figure 2. Transcriptional and post-transcriptional regulation of multi-ciliated cells. (A) Transcriptional control of core MCC gene expression in multi-ciliated cells. Arrows = activation, T = inhibition, solid line = major contribution, dotted line = supporting contribution. (B) A transcriptional/post-transcriptional regulatory module titrates levels of Cp110 to allow for ciliogenesis in MCCs. Left panel: cp110, miR-34b/c, and miR-449a-c are directly regulated by ciliary transcription factors (color code is the same as in A). Right panel: optimal (intermediate) Cp110 levels are required for ciliogenesis. Summary of effects of too much or too little Cp110 on MCC cilia formation Image published in: Walentek P and Quigley IK (2017) Copyright © 2017. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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