Xenbase Image ID: 154784

Figure 3. Signaling regulation in the Xenopus mucociliary epidermis. Overview of signaling regulation and development of the mucociliary epidermis. (A) Developmental processes over the time-course of mucociliary epithelium formation. Corresponding stages of Xenopus development are depicted on the left. Digitized images and developmental data from Nieuwkoop and Faber (1994) Normal Table of Xenopus laevis (Daudin) were obtained from Xenbase.org. (B) Schematic summary of signaling events and key transcription factors regulating mucociliary cell fate specification. Binary decisions based on high versus low level input from signaling events are shown as triangle representing two sides of a signaling gradient (for BMP, Wnt and Notch). Additional contributions from signaling pathways are depicted as, for example, “+Wnt.” In later stages, BMP signaling (yellow) is also required for intercalation of all cell types derived from subepithelial progenitors Image published in: Walentek P and Quigley IK (2017) Copyright © 2017. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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