XB-IMG-154808
Xenbase Image ID: 154808
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FIG. 1. Amino acid sequence and homology of mTFR11. (A)
Translated amino acid sequence of the mTFR11 cDNA. The signal
peptide and transmembrane domains are indicated by a single
underline. Potential sites of N-linked glycosylation are indicated by
asterisks. The ends of the kinase domain are indicated by arrows.
Ten of the conserved cysteine residues in the extracellular domain
are in reverse print. Type I box is indicated by a double underline.
An arrowhead is under the tyrosine residue that changes to stop
codon in the dominant negative BMP receptor. (B) Homology of the
mTFR11/hALK-3 to other receptors for ligands of the TGF-(3
superfamily. Percent amino acid identity is indicated. Light-shaded
boxes, extracellular domain; black boxes, transmembrane domain;
dark-shaded boxes, type I box; hatched boxes, intracellular kinase
domain. ALK-2, -3, -5, and -6, activin receptor-like kinases 2, 3, 5,
and 6(26); xTFR11, Xenopus TFR11 (accession no. D32066); mTGFf3RI,
mouse TGF-(3 type I receptor (27); mActRI, mouse activin type
I receptor (28); mActRII, mouse activin type II receptor (13);
mTGF-fBRII, mouse TGF-f type II receptor (29);daf4, C. elegans
daf-4 gene product (30). Image published in: Suzuki A et al. (1994) Copyright © 1994. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |