Xenbase Image ID: 154836

Figure 2. Gene ontology and expression patterns for differentially expressed genes during regeneration, Clusters I–IV. (a) Cluster I contains genes that are highly expressed in the tail tip, downregulated from 0 to 6 hpa, and then re-upregulated. (b) Cluster II contains genes that are highly expressed in the whole tail and are downregulated steadily over the course of regeneration. Cluster III contains genes that are strongly expressed in the transected trunk at 0hpa, and are downregulated during regeneration. Cluster IV contains genes that are upregulated in the first few hours post amputation and then downregulated. Heat maps of expression values uses the same color key as Figure 1c. Top gene ontology enrichment terms were identified using EnrichR, and are shown with the corresponding –log10 of their adjusted p value. Higher –log10 represents more significant terms. P values are adjusted to take into account multiple hypothesis testing. WhT = Whole tail. Hpa = hours post amputation. Image published in: Chang J et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

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