Xenbase Image ID: 155016

Figure 4. The frog dorsal center can induce epidermal differentiation at a distance. (a)Cytokeratin mRNA marks the epidermis, a region of high BMP signaling in the Xenopus embryo at neural plate stage. (b) When four BMPs are depleted by knocking down simultaneously BMP2/4/7 and ADMP with antisense Morpholino oligonucleotides, the entire ectoderm is converted to central nervous system tissue as indicated by the absence of Cytokeratin mRNA staining. (c) Transplantation of a wild-type (WT) dorsal center into an embryo depleted of BMPs restores dorsal–ventral patterning and epidermal differentiation at a distance. The transplanted wild-type tissue, which was labeled with the lineage tracer nuclear-LacZ, gives rise to notochord. These experiments show that the dorsal center is a source of BMP ligands that are transported and induce BMP signaling at a distance. Adapted from [47], with permission. Image published in: Plouhinec JL et al. (2011) Copyright © 2011. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue krt12.4.L ck81, cytok, cytokeratin, E-keratin, epi-keratin, epidermal keratin, Epidermis-specific keratin, EpiK, epiker, EpK, epK, K81, xK81, xk81a, xk81a1 X. laevis Throughout NF stage 18 non-neural ectoderm Image source: Published Larger Image Printer Friendly View

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