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FIGURE 4:. TACC family members are differentially expressed during embryonic development. Cell type–specific expression of TACC mRNAs shown by whole-mount in situ hybridization using full-length antisense probes to TACC1, TACC2, and TACC3. TACC1 is expressed uniformly at the late blastula stage (A), in somites, neural tube, and hindbrain at stage 23 (B), and in somites, eye, and anterior neural tube at stage 34 (C, D). TACC2 expression is similar to that of TACC1 at the blastula stage (E) and also increases in a tissue-specific manner after neurulation, apparent in the neural tube, early brain, and presomitic mesoderm at stage 23 (F). At stage 34, TACC2 is expressed in the somitic mesoderm, the ocular lens, and the anterior neural tube (G, H). Arrows in D and H indicate somitic mesoderm. TACC3 expression resembles that of TACC1 and TACC2 at the blastula stage (I), but its expression becomes more neural specific by stage 23, showing expression along the entire length of the neural tube, although strongest anteriorly near the brain (J). At stage 34, TACC3 is strongly expressed in the pharyngeal arches (L, arrows), otic vesicle, and trunk neural crest (K, L). Neural tube and trunk neural crest are indicated by the box in L. Scale bars, 150 μm. Image published in: Rutherford EL et al. (2016) © 2016 Rutherford, Carandang, et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license Gene Synonyms Species Stage(s) Tissue tacc1.L X. laevis Throughout NF stage 10 whole organism tacc1.L X. laevis Throughout NF stage 23 somite neural tube hindbrain spinal cord tacc1.L X. laevis Throughout NF stage 33 and 34 somite epaxial muscle central nervous system brain eye tacc2.L X. laevis Throughout NF stage 10 whole organism tacc2.L X. laevis Throughout NF stage 23 somite neural tube anterior neural tube tacc2.L X. laevis Throughout NF stage 33 and 34 somite epaxial muscle central nervous system brain eye tacc3.L eric1, maskin, xmaskin X. laevis Throughout NF stage 10 whole organism tacc3.L eric1, maskin, xmaskin X. laevis Throughout NF stage 23 neural tube tacc3.L eric1, maskin, xmaskin X. laevis Throughout NF stage 33 and 34 pharyngeal arch central nervous system brain spinal cord eye mandibular arch hyoid arch branchial arch forebrain midbrain hindbrain Image source: Published Larger Image Printer Friendly View

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