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Figure 4. Se content in ten mouse tissues as a function of ZIP8 concentrations in three mouse lines having different Slc39a8 genotypesA. Intracellular Se content, 2 h after IP selenite (2.5 mg/kg) administration to the ZIP8-over-expressing BTZIP8-3 mouse line (solid red bar; N=6), the ZIP8-normal-expressing wild-type (WT; pink bar; N=9), and the hypomorph ZIP8 Slc39a8(+/neo) line; (open bar; N=9). Red brackets (S.E.M.) depict statistical differences between BTZIP8-3 and Slc39a8(+/neo); black brackets (S.E.M.) signify statistical differences between BTZIP8-3 and WT. *P <0.05, **P <0.01. Animals (2-3 months of age) included similar numbers of males and females; we first had determined that no sex differences existed. B–F. ZIP8 immunofluorescence in 10-μm tissue sections from WT vs BTZIP8-3 mice. White bar (in panel B) = 50 μm for panels B through E; white bar (in panel F) = 10 μm. Image published in: McDermott JR et al. (2016) Copyright: © 2016 McDermott et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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