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XB-IMG-155620

Xenbase Image ID: 155620

Fig 6. Analysis of macroscopic inactivation in female myocytes with different KChIP2 genotypes.Outward currents were activated by 5 s voltage pulses from -80 to +40 mV in female KChIP2+/+, KChIP2+/- and KChIP2-/- myocytes. A. Representative current traces for the different KChIP2 genotypes were normalized to peak and only the inactivating current components are shown (voltage protocol below current traces; dotted line represents non-inactivating current level). Current decay kinetics in KChIP2+/+ (grey), KChIP2+/- (orange) and most KChIP2-/- myocytes (14 out of 17, blue, fast decay) were best described by a triple-exponential function. In some KChIP2-/- myocytes (3 out of 17, blue, slow decay) a double-exponential function was sufficient. B. Mean time constants obtained with a triple-exponential function (τ1, τ2 and τ3) for female KChIP2+/+ (grey bars), KChIP2+/- (orange bars) and most KChIP2-/- myocytes (14 out of 17, blue bars), and mean time constants obtained with a double-exponential function for 3 out of 17 female KChIP2-/- myocytes (τ2 and τ3, separate blue bars on the right). C. Mean amplitudes of the individual time constants obtained by triple-exponential (A1, A2 and A3) and double-exponential fitting (A2 and A3, separate bars on the right) and mean amplitudes of the corresponding non-inactivating current components (A0, A0). Like in male myocytes, there was a gene dosage effect on A1 in female myocytes (* significantly different from KChIP2+/+; ** significantly different from both KChIP2+/+ and KChIP2+/-; one-way ANOVA). D. Mean total amplitudes of the compound outward current (AΣ, AΣ). The KChIP2 gene dosage effect observed for A1 is not reflected in AΣ in female myocytes.

Image published in: Waldschmidt L et al. (2017)

© 2017 Waldschmidt et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license

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