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Fig 7. Recovery from inactivation and voltage dependence of inactivation in female myocytes with different KChIP2 genotypes.Recovery from inactivation and the voltage dependence of inactivation were studied in female KChIP2+/+ (grey symbols), KChIP2+/- (orange symbols) and KChIP2-/- myocytes (blue symbols). A. Recovery plots. Fitting curves represent double-exponential functions. Lines without symbols represent single-exponential functions fitted to a fraction of the data points (the fast component) and forced to reach 1. Note that in female myocytes a moderate apparent slowing of the recovery kinetics was observed for KChIP2+/- compared to KChIP2+/+. B. Mean recovery time constants (τrec1 and τrec2) obtained by fitting the recovery kinetics with a double-exponential function. C. Mean relative amplitudes of recovery time constants for all KChIP2 genotypes (Arec1 and Arec2). D. Inactivation curves. The data were fitted with the sum of two Boltzmann-functions. Lines without symbols represent single Boltzmann-functions fitted to a fraction to the data points (the more negative portion) and forced to reach 0. E. Mean values for V1/21 and V1/22 obtained with the sum of two Boltzmann-functions. Note that V1/22 values are similar in all KChIP2 genotypes. F. Mean relative amplitudes of the voltage dependences defined by V1/21 and V1/22 (Av1 and Av2); * significantly different from KChIP2+/+; ** significantly different from both KChIP2+/+ and KChIP2+/-; one-way ANOVA. Image published in: Waldschmidt L et al. (2017) © 2017 Waldschmidt et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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